You can setup Pepakura using Wineskin Winery.
1. Make sure you have bought and downloaded Pepakura Viewer or Designer depending on what you exactly need and have the .EXE.
2. Go to
http://wineskin.urgesoftware.com/tiki-index.php download and install the program from the DMG.
3. Launch Wineskin Winery. From here we'll need to grab a New Engine. Make sure you use 1.5.14 (do not select the AMDspeedhack) or else you'll never be able to select a default exe and have to go through the "install process" every time. From here highlight the 1.5.14 engine by clicking once and hit "Create New Blank Wrapper". Once you do this you'll name your app (call it Pepakura or whatever you'd like) the first time you'll receive notifications to install Wine Mono and Wine Gecko, go ahead and do this. Once it's finished you'll get the option to view your wrapper in Finder and just move it to your desktop.
4. Double click on the wrapper/app we created and click "Install Software", from here navigate to your pepakura installer.exe file and select it. From there you will install it like a normal Windows program. Deselect "Create Shortcut on Desktop" as it's useless in this case, if you forget it'll simply just create a .INK file you can delete later from your desktop.
5. You will receive an invalid error, don't worry about it just hit okay and Pepakura will launch, you will receive this error each time but don't be alarmed. At this point quit out of the Pepakura app you just created (CMD+Q). You should receive a notification that you need to select a default .exe. Make sure you select pepakura3.exe from the list. You can now relaunch Pepakura easily each time and enter your key code to unlock the full version, you will only have to enter your code once on the next launch.
As far as I can tell all functionality is here and you can print as well without a problem.